Effects of therapeutic agents on cyclic amp metabolism in vitro
Identifieur interne : 003B31 ( Main/Exploration ); précédent : 003B30; suivant : 003B32Effects of therapeutic agents on cyclic amp metabolism in vitro
Auteurs : I. Weinryb [États-Unis] ; M. Chasin [États-Unis] ; C. A. Free [États-Unis] ; D. N. Harris [États-Unis] ; H. Goldenberg [États-Unis] ; I. M. Michel [États-Unis] ; V. S. Paik [États-Unis] ; M. Phillips [États-Unis] ; S. Samaniego [États-Unis] ; S. M. Hess [États-Unis]Source :
- Journal of Pharmaceutical Sciences [ 0022-3549 ] ; 1972-10.
English descriptors
- Teeft :
- Adenylate, Adenylate cyclase, Adenylate cyclase activity, Adrenal, Adrenal cell, Adrenal cells, Adrenal lung adenylate cyclase, Amitriptyline, Analog, Anthelmintic, Antineoplastic, Antiparasitic agents, Antipsychotic, Assay, Basal, Basal activity, Brain phosphodiesterase, Brain phosphodiesterase activity, Bunamidine, Chlorpromazine, Compound, Cyclase, Cyclase activity, Cyclic, Cyclic nucleotide phosphodiesterase, Cyproheptadine, Drug classes, Edrophonium bromide, Emulsion, Ephedrine, Epinephrine, Equimolar, Equimolar theophylline, Ethinyl estradiol, Fluphenazine, Heart enzyme, Heart phosphodiesterase, Hydrochloride, Hydroxychloroquine, Hydroxychloroquine analog, Incubation mixtures, Inhibition, Inhibitor, Iodochlorhydroxyquin, Isoproterenol, Large number, Lipolysis, Lipolytic, Loo0, Lower concentrations, Lung cyclase activity, Metabolism, Nucleotide, Pamoate, Percent inhibition, Pharmacological activities, Phenylephrine hydrochloride, Phosphodiesterase, Phosphodiesterase activity, Potent inhibitors, Power parameters, Promethazine, Pyrvinium, Pyrvinium pamoate, Steroidogenesis, Strong inhibitors, Sulfate, Theophylline, Therapeutic agents, Therapeutic classes, Thioridazine, Tolbutamide.
Abstract
One hundred and fifty‐eight compounds representing 49 classes of therapeutic agents were examined for their effects on steroidogenesis in isolated rat adrenal cells, on lipolysis in isolated rat lipocytes, on the activity of guinea pig lung adenylate cyclase, and on the activity of rat brain and cat heart cyclic nucleotide phosphodiesterase preparations. Classes of drugs active in the CNS appeared particularly active in the in vitro systems investigated, as did antiparasitic agents. Experience with general screening of compounds for effects on phosphodiesterase activity, along with data reported here, indicated a correlation between compounds with pharmacological activity in vivo and inhibition of phosphodiesterase activity in vitro. This is not to say that the pharmacological activities of the compounds necessarily arise from alterations of adenosine‐3′,5′‐monophosphate (cyclic AMP) metabolism.
Url:
DOI: 10.1002/jps.2600611003
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000251
- to stream Istex, to step Curation: 000251
- to stream Istex, to step Checkpoint: 002873
- to stream Main, to step Merge: 003C11
- to stream Main, to step Curation: 003B31
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of therapeutic agents on cyclic amp metabolism in vitro</title><author><name sortKey="Weinryb, I" sort="Weinryb, I" uniqKey="Weinryb I" first="I." last="Weinryb">I. Weinryb</name></author><author><name sortKey="Chasin, M" sort="Chasin, M" uniqKey="Chasin M" first="M." last="Chasin">M. Chasin</name></author><author><name sortKey="Free, C A" sort="Free, C A" uniqKey="Free C" first="C. A." last="Free">C. A. Free</name></author><author><name sortKey="Harris, D N" sort="Harris, D N" uniqKey="Harris D" first="D. N." last="Harris">D. N. Harris</name></author><author><name sortKey="Goldenberg, H" sort="Goldenberg, H" uniqKey="Goldenberg H" first="H." last="Goldenberg">H. Goldenberg</name></author><author><name sortKey="Michel, I M" sort="Michel, I M" uniqKey="Michel I" first="I. M." last="Michel">I. M. Michel</name></author><author><name sortKey="Paik, V S" sort="Paik, V S" uniqKey="Paik V" first="V. S." last="Paik">V. S. Paik</name></author><author><name sortKey="Phillips, M" sort="Phillips, M" uniqKey="Phillips M" first="M." last="Phillips">M. Phillips</name></author><author><name sortKey="Samaniego, S" sort="Samaniego, S" uniqKey="Samaniego S" first="S." last="Samaniego">S. Samaniego</name></author><author><name sortKey="Hess, S M" sort="Hess, S M" uniqKey="Hess S" first="S. M." last="Hess">S. M. Hess</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6F267356FCDC15590BDCF4CA3067A308D14BC9CB</idno><date when="1972" year="1972">1972</date><idno type="doi">10.1002/jps.2600611003</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-5M5XVB4J-V/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000251</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000251</idno><idno type="wicri:Area/Istex/Curation">000251</idno><idno type="wicri:Area/Istex/Checkpoint">002873</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002873</idno><idno type="wicri:doubleKey">0022-3549:1972:Weinryb I:effects:of:therapeutic</idno><idno type="wicri:Area/Main/Merge">003C11</idno><idno type="wicri:Area/Main/Curation">003B31</idno><idno type="wicri:Area/Main/Exploration">003B31</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Effects of therapeutic agents on cyclic amp metabolism in vitro</title><author><name sortKey="Weinryb, I" sort="Weinryb, I" uniqKey="Weinryb I" first="I." last="Weinryb">I. Weinryb</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Biochemical Pharmacology, Squibb Institute for Medical Research, New Brunswick</wicri:cityArea></affiliation></author><author><name sortKey="Chasin, M" sort="Chasin, M" uniqKey="Chasin M" first="M." last="Chasin">M. Chasin</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Biochemical Pharmacology, Squibb Institute for Medical Research, New Brunswick</wicri:cityArea></affiliation></author><author><name sortKey="Free, C A" sort="Free, C A" uniqKey="Free C" first="C. A." last="Free">C. A. Free</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Biochemical Pharmacology, Squibb Institute for Medical Research, New Brunswick</wicri:cityArea></affiliation></author><author><name sortKey="Harris, D N" sort="Harris, D N" uniqKey="Harris D" first="D. N." last="Harris">D. N. Harris</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Biochemical Pharmacology, Squibb Institute for Medical Research, New Brunswick</wicri:cityArea></affiliation></author><author><name sortKey="Goldenberg, H" sort="Goldenberg, H" uniqKey="Goldenberg H" first="H." last="Goldenberg">H. Goldenberg</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Biochemical Pharmacology, Squibb Institute for Medical Research, New Brunswick</wicri:cityArea></affiliation></author><author><name sortKey="Michel, I M" sort="Michel, I M" uniqKey="Michel I" first="I. M." last="Michel">I. M. Michel</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Biochemical Pharmacology, Squibb Institute for Medical Research, New Brunswick</wicri:cityArea></affiliation></author><author><name sortKey="Paik, V S" sort="Paik, V S" uniqKey="Paik V" first="V. S." last="Paik">V. S. Paik</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Biochemical Pharmacology, Squibb Institute for Medical Research, New Brunswick</wicri:cityArea></affiliation></author><author><name sortKey="Phillips, M" sort="Phillips, M" uniqKey="Phillips M" first="M." last="Phillips">M. Phillips</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Biochemical Pharmacology, Squibb Institute for Medical Research, New Brunswick</wicri:cityArea></affiliation></author><author><name sortKey="Samaniego, S" sort="Samaniego, S" uniqKey="Samaniego S" first="S." last="Samaniego">S. Samaniego</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Biochemical Pharmacology, Squibb Institute for Medical Research, New Brunswick</wicri:cityArea></affiliation></author><author><name sortKey="Hess, S M" sort="Hess, S M" uniqKey="Hess S" first="S. M." last="Hess">S. M. Hess</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Biochemical Pharmacology, Squibb Institute for Medical Research, New Brunswick</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Correspondence address: Department of Biochemical Pharmacology, Squibb Institute for Medical Research, New Brunswick</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Pharmaceutical Sciences</title><title level="j" type="alt">JOURNAL OF PHARMACEUTICAL SCIENCES</title><idno type="ISSN">0022-3549</idno><idno type="eISSN">1520-6017</idno><imprint><biblScope unit="vol">61</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1556">1556</biblScope><biblScope unit="page" to="1567">1567</biblScope><biblScope unit="page-count">12</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Washington</pubPlace><date type="published" when="1972-10">1972-10</date></imprint><idno type="ISSN">0022-3549</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3549</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adenylate</term><term>Adenylate cyclase</term><term>Adenylate cyclase activity</term><term>Adrenal</term><term>Adrenal cell</term><term>Adrenal cells</term><term>Adrenal lung adenylate cyclase</term><term>Amitriptyline</term><term>Analog</term><term>Anthelmintic</term><term>Antineoplastic</term><term>Antiparasitic agents</term><term>Antipsychotic</term><term>Assay</term><term>Basal</term><term>Basal activity</term><term>Brain phosphodiesterase</term><term>Brain phosphodiesterase activity</term><term>Bunamidine</term><term>Chlorpromazine</term><term>Compound</term><term>Cyclase</term><term>Cyclase activity</term><term>Cyclic</term><term>Cyclic nucleotide phosphodiesterase</term><term>Cyproheptadine</term><term>Drug classes</term><term>Edrophonium bromide</term><term>Emulsion</term><term>Ephedrine</term><term>Epinephrine</term><term>Equimolar</term><term>Equimolar theophylline</term><term>Ethinyl estradiol</term><term>Fluphenazine</term><term>Heart enzyme</term><term>Heart phosphodiesterase</term><term>Hydrochloride</term><term>Hydroxychloroquine</term><term>Hydroxychloroquine analog</term><term>Incubation mixtures</term><term>Inhibition</term><term>Inhibitor</term><term>Iodochlorhydroxyquin</term><term>Isoproterenol</term><term>Large number</term><term>Lipolysis</term><term>Lipolytic</term><term>Loo0</term><term>Lower concentrations</term><term>Lung cyclase activity</term><term>Metabolism</term><term>Nucleotide</term><term>Pamoate</term><term>Percent inhibition</term><term>Pharmacological activities</term><term>Phenylephrine hydrochloride</term><term>Phosphodiesterase</term><term>Phosphodiesterase activity</term><term>Potent inhibitors</term><term>Power parameters</term><term>Promethazine</term><term>Pyrvinium</term><term>Pyrvinium pamoate</term><term>Steroidogenesis</term><term>Strong inhibitors</term><term>Sulfate</term><term>Theophylline</term><term>Therapeutic agents</term><term>Therapeutic classes</term><term>Thioridazine</term><term>Tolbutamide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">One hundred and fifty‐eight compounds representing 49 classes of therapeutic agents were examined for their effects on steroidogenesis in isolated rat adrenal cells, on lipolysis in isolated rat lipocytes, on the activity of guinea pig lung adenylate cyclase, and on the activity of rat brain and cat heart cyclic nucleotide phosphodiesterase preparations. Classes of drugs active in the CNS appeared particularly active in the in vitro systems investigated, as did antiparasitic agents. Experience with general screening of compounds for effects on phosphodiesterase activity, along with data reported here, indicated a correlation between compounds with pharmacological activity in vivo and inhibition of phosphodiesterase activity in vitro. This is not to say that the pharmacological activities of the compounds necessarily arise from alterations of adenosine‐3′,5′‐monophosphate (cyclic AMP) metabolism.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>New Jersey</li></region></list><tree><country name="États-Unis"><region name="New Jersey"><name sortKey="Weinryb, I" sort="Weinryb, I" uniqKey="Weinryb I" first="I." last="Weinryb">I. Weinryb</name></region><name sortKey="Chasin, M" sort="Chasin, M" uniqKey="Chasin M" first="M." last="Chasin">M. Chasin</name><name sortKey="Free, C A" sort="Free, C A" uniqKey="Free C" first="C. A." last="Free">C. A. Free</name><name sortKey="Goldenberg, H" sort="Goldenberg, H" uniqKey="Goldenberg H" first="H." last="Goldenberg">H. Goldenberg</name><name sortKey="Harris, D N" sort="Harris, D N" uniqKey="Harris D" first="D. N." last="Harris">D. N. Harris</name><name sortKey="Hess, S M" sort="Hess, S M" uniqKey="Hess S" first="S. M." last="Hess">S. M. Hess</name><name sortKey="Hess, S M" sort="Hess, S M" uniqKey="Hess S" first="S. M." last="Hess">S. M. Hess</name><name sortKey="Michel, I M" sort="Michel, I M" uniqKey="Michel I" first="I. M." last="Michel">I. M. Michel</name><name sortKey="Paik, V S" sort="Paik, V S" uniqKey="Paik V" first="V. S." last="Paik">V. S. Paik</name><name sortKey="Phillips, M" sort="Phillips, M" uniqKey="Phillips M" first="M." last="Phillips">M. Phillips</name><name sortKey="Samaniego, S" sort="Samaniego, S" uniqKey="Samaniego S" first="S." last="Samaniego">S. Samaniego</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003B31 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003B31 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:6F267356FCDC15590BDCF4CA3067A308D14BC9CB
|texte= Effects of therapeutic agents on cyclic amp metabolism in vitro
}}
| This area was generated with Dilib version V0.6.33. |  |